For several years, observed increased rates of AST and ALT (2-3 times above normal). All tests for exposure to the virus B and C are negative (including RT-PCR). Analyses rented many times in Russia and abroad. All the doctors argue that exposure to the virus was not. Odnaznachno reply to a question about the increase of ALT and AST, they can not. , A few years I took numerous medications related to hepatoprotectors (SAMe, etc.) - the situation has not changed. Alkogol not drink already 4-5 years. The doctors are suspected of reducing the function of the biliary system (ultrasound shows a modified form of bubble - probably innate, but that does not affect the vydelitelnuyu system. How dangerous a persistent increase of ALT and AST?

Respond Stepanova Tatjana, a gastroenterologist, hepatologist should know the reason for increase of transaminases. There are several: the toxic effect of what - or substances: alcohol, drugs, etc., the impact of viruses, autoimmune diseases, concomitant diseases, leading to an increase in enzymes, liver steatosis (fatty rearrangement). Increased transaminases may be on the background of biliary dyskinesia. The risk increase of ALT and AST depends on the cause, which causes dysfunction. Need a doctor's consultation - hepatologist. A similar question: ... 6-14 bilirubin, alkaline phosphatase - the norm. repeatedly handed antibody viruses B, C - negative PCR passed to B. ..